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#Spike protein dna damage windows
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“Our work helps to elucidate changes occurring in patients on the genetic level, which could eventually provide insight into which treatments would work best for specific patients,” said Evans. The top genes included ones related to inflammatory response. The researchers found that cultured human airway cells exposed to both low and high concentrations of purified S protein showed differences in gene expression that remained even after the cells recovered from the exposure. This involved exposing cells to air and then giving them time to mature into airway cells.
The researchers optimised a previously developed culturing approach known as the air-liquid interface technique so that it would more closely simulate the physiological conditions found in the lung airway. Culturing human airway cells requires specific conditions that allow cells to mature into the differentiated cells that would be found in the airway.
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